2,2-Difluoroethyl Acetate

Oxidising properties

Link to relevant study record(s)

Reference

Endpoint:

oxidising liquids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 08 July 2014 to 22 October 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.21 (Oxidising Properties (Liquids))

GLP compliance:

yes (incl. QA statement)

Contact with:

powdered cellulose

Key result

Sample tested:

test mixture 1:1

Parameter:

mean pressure rise time

Result:

21.2 s

Sample tested:

reference mixture with 65% nitric acid + cellulose (1:1 ratio)

Parameter:

mean pressure rise time

Result:

6 s

Pressure Rise Times for Test and Reference Mixtures:

Mixture	Run	Pressure rise time (seconds)	Mean pressure rise time (seconds)
Cellulose/Test substance	1	22.1	21.2
	2	12.8
	3	13.9
	4	35.3
	5	21.7
Cellulose/Reference substance	1	7.24	5.96
	2	5.21
	3	7.50
	4	4.78
	5	5.06

The mean pressure rise time for the reference mixture (1:1 w/w mixture of 65% w/w aqueous nitric acid and cellulose) was 6.0 seconds, while the mean pressure rise time for the test substance mixture (1:1 w/w mixture of the test substance and cellulose) was 21.2 seconds.

 

Since the mean pressure rise time and also the minimum pressure rise time for the test substance/cellulose mixture were much greater than that for the reference substance/cellulose mixture, the test substance was considered to be not oxidising.

Interpretation of results:

GHS criteria not met

Conclusions:

2,2-Difluoroethyl acetate was demonstrated not to be an oxidizing liquid.

Executive summary:

The oxidising properties of 2,2-Difluoroethyl acetate was investigated in a GLP-compliant study according to the EU A.21 method. The mean pressure rise time of 2,2-Difluoroethyl acetate mixed with cellulose (1:1 ww ratio) was compared to the mean pressure rise time of a reference substance (65% w/w aqueous nitric acid) mixed with cellulose (1:1 ww ratio). Since the mean pressure rise time and also the minimum pressure rise time for the test substance/cellulose mixture were much greater than that for the reference substance/cellulose mixture, 2,2-Difluoroethyl acetate was considered to be non-oxidising.

Description of key information

2,2-Difluoroethyl acetate has no oxidizing properties.

Key value for chemical safety assessment

Oxidising properties:

non oxidising

Additional information

An experimental study performed under GLP compliance and in accordance with EU A.21 method was flagged as a key study and assigned a Klimisch score of 1. It reports that 2,2-Difluoroethyl acetate has no oxidising properties.

Justification for classification or non-classification

Based on the above described information, 2,2-Difluoroethyl acetate does not need to be classified for its oxidizing properties under CLP.