Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
other: Metal block method and differential scanning calorimetry method

Test material

Constituent 1
Chemical structure
Reference substance name:
(2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride
Cas Number:
2171323-89-8
Molecular formula:
C18H20CIF2NO2
IUPAC Name:
(2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride
Specific details on test material used for the study:
Substance name: BFPA HCl salt
Lot #: SS17000577 (TSN400390)
Purity: 100%

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
152 °C

Applicant's summary and conclusion

Conclusions:
Melting temperature: 152°C
Executive summary:

The study was conducted according to OECD guideline 102, EEC method A.1, and OPPTS 830.7200.


The melting temperature was assessed by the metal block method using a calibrated digital melting point apparatus and also by differential scanning calorimetry (DSC) using a thermogravimetric analysis (TGA) instrument.


The melting temperature of the test substance was determined to be 152°C, although there were some morphology changes prior to melting.