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Density

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Reference
Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 Aug 2017 - 18 Jan 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.3 (Relative Density)
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
pycnometer method
Key result
Type:
relative density
Density:
1.236 other: dimensionless
Temp.:
20 °C
Remarks on result:
other: mean value of 2 determinations

Literature data (CRC Handbook of Chemistry and Physics 75th Edition)


d (20, w) (density of water at 20 °C) = 0.9982 g/mL


d (4, w) (density of water at 4 °C) = 0.99997 g/mL


d (20, a) (density of air at 20 °C) = 0.0012 g/mL


 


Validity criteria for the measurement of the density:




















Target condition according to guideline:Actual condition according to the study:Validity criteria met:
The test is done at constant temperature, preferably at 20°C.The pycnometer was thermostated at 20 °C in a water bath until the readings of the filling height remained constant.Yes
Duplicate measurements are required.Two measurements are performed.Yes

 

Conclusions:
The density of Fluocortolon-A-Acetat at 20 ºC was 1.236 g/cm3 and the relative density was 1.236.
Executive summary:

The relative density of Fluocortolon-A-Acetat was determined according to the OECD Guideline 109 (Density of Liquids and Solids) corresponding to A.3., Council Regulations EC No 440/2008. The solid sample was accurately weighed into a 20 mL pycnometer and by displacement of the solvent (n-heptan), its equivalent volume was determined. Finally, the density of Fluorcortolon-A-Acetat was calculated. The relative density at 20 ºC was 1.236 g/cm³ and the relative density was 1.236.

Description of key information

The relative density of Fluocortolon-A-Acetat was determined according to the OECD Guideline 109 (Density of Liquids and Solids) corresponding to A.3., Council Regulations EC No 440/2008 by pycnometer method. The relative density at 20 ºC was 1.236 g/cm3and the relative density was 1.236.

Key value for chemical safety assessment

Relative density at 20C:
1.236

Additional information