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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2021

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
(R)-thiazolidine-4-carboxylic acid
EC Number:
252-106-3
EC Name:
(R)-thiazolidine-4-carboxylic acid
Cas Number:
34592-47-7
Molecular formula:
C4H7NO2S
IUPAC Name:
(R)-thiazolidine-4-carboxylic acid
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
Batch number: 20190104
Expiry date: January 01, 2021

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
yes
Details on test solutions:
The test was performed at only one test item concentration 100.0 mg test item/L. Prior to the test start, a 100.0 mg test item/L stock solution was prepared by direct weighting 0.0199 g of test item into 199 mL reconstituted water.

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h

Test conditions

Test temperature:
20.0 – 20.1°C.
pH:
negative control: 7.07 - 7.14; test item solution: 6.62 – 6.87.
Dissolved oxygen:
negative control: 6.21 – 6.12 mg O2/L
test item solution: 6.25 – 6.22 mg O2/L.
Nominal and measured concentrations:
100 mg/l

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
IC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Details on results:
Since all analytical recoveries were in the range 80 % - 120 % of the nominal concentrations,
the biological results were referred to the test item nominal concentrations.

The daphnids were observed for immobility after 24 and 48 hours of exposure.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The EC10, the EC20, the EC50 value and the NOEC at 24 and 48 hours were assessed.
The results, calculated in terms of nominal test item concentrations, were as follows:
EC50 24H and 48h: > 100 mg/l
NOEC 24H and 48h: 100 mg/l