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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1-12 Feb 1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
adjustment of the solution equilibrium as in CIPAC MT 157 part 2
Qualifier:
according to guideline
Guideline:
other: CIPAC method MT 157, Part 2
GLP compliance:
yes
Type of method:
column elution method
Water solubility:
610 mg/L
Temp.:
20 °C
pH:
>= 4 - <= 9
Remarks on result:
other: the solubility is independent of the pH in the range between 4 and 9

Summary of results

Water

Run

Concentration as function of equilibration time (mg/L)

0.5 h

1 h

2 h

4 h

8 h

24 h

57 h

72 h

Unbuffered in equilibrium with CO2

1st

603.8

622.6

612.8

608.3

609.3

(559.7)

-

-

2nd

-

-

-

-

598.3

581.0

640.3

641.2

Mean

613.1

Standard deviation 19.3

Acidic, pH 4, phosphate buffer

1st

607.3

606.0

601.4

600.0

608.2

(555.0)

-

-

2nd

-

-

-

-

655.4

605.6

612.4

612.7

Mean

563.8

Standard deviation 23.3

Alkaline, pH 9, borate buffer

1st

582.6

591.3

576.6

596.2

591.7

(532.4)

-

-

2nd

-

-

-

-

644.2

603.9

612.2

611.0

Mean

601.1

Standard deviation 20.1

As it is evident from the concentration measurements, the solubility equilibrium is reached after 30 mins. of stirring. The 24 hrs. values from the first runs were not included in the calculation of mean and standard deviation.

Description of key information

610 mg/L at 20 °C, pH=4-9

Key value for chemical safety assessment

Water solubility:
610 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined using flask method according to CIPAC MT 157, Part 2, similar to OECD 105.