Registration Dossier
Registration Dossier
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EC number: 216-885-3 | CAS number: 1689-99-2
Endpoint summary
Administrative data
Description of key information
The substance was tested on different aquatic organisms, representing the three trophic levels: fish, invertebrates and algae; furthermore, testing on microorganisms also is available. With respect to fish and aquatic organisms, data are available for both freshwater and marine water.
The 96-hour LC50 for fish exposed to the present test material was 0.041 mg a.i./L for O. mykiss in freshwater.
The 96-hour LC50 for fish exposed to the present test material was 0.170 mg a.i./L for C. variegatus in saltwater.
The 48-hour EC50 for aquatic invertebrates exposed to the present test material was 0.03 mg a.i./L for D. magna in freshwater.
The 96-hour LC50 for aquatic invertebrates exposed to the present test material was 0.087 mg a.i./L for M. bahia in saltwater.
The 120-h ErC50 for algae exposed to the present test material was 0.22 mg a.i./L for P. subcapitata in freshwater.
The NOEC for early life stage of P. promelas was 0.0049 mg a.i./L.
The 21-day NOEC for aquatic invertebrates exposed to the present test material was 0.0036 mg a.i./L for D. magna in freshwater.
The 120-h ErC10 for algae exposed to the present test material was 0.0087 mg a.i./L for P. subcapitata in freshwater.
The 3-hour EC50 for microorganisms exposed to the present test material was > 1000 mg /L.
Additional information
The substance was tested on aquatic organisms of different trophic levels (fish, invertebrates, algae, aquatic plants and activated sludge).
A short-term key toxicity study assessed the effects on fish, according to OECD 203 performed with the rainbow trout (O. mykiss, 96 h, freshwater). The acute effect value in fish was determined in with an LC50(96h) of 0.041 mg a.i./L (mean measured).
The long-term effects of the substance towards fish were examined in a flow-through 35-day early-life stage toxicity test with Pimephales promelas according to EPA OPP 72-4. A NOEC (35d) of 0.0049 mg a.i./L (mean measured) was determined as the derived chronic value.
Aquatic invertebrates were the most sensitive organisms when exposed to the test substance. In an acute toxicity test on the freshwater invertebrate (OECD 202), Daphnia magna, immobility was assessed, resulting in an EC50(48 h) of 0.03 mg a.i./L (mean measured).
The long-term effects of the substance towards Daphnia magna were examined in a 21-day toxicity test according to EPA OPP 72-4. A NOEC (21d) of 0.0036 mg a.i./L (mean measured) was determined.
The toxicity of the substance to aquatic algae was investigated in a study performed according to EPA OPP 122-2 with freshwater algae P. subcapitata. The 120-h ErC50and ErC10were 0.22 mg a.i./L and 0.0087 mg a.i./L, respectively, based on mean measured concentrations.
The effect of the substance on the respiration rate of microorganisms (activated sludge) was examined in a dose-response test. The EC50(3 h) was determined to be > 1000 mg/L (nominal). Thus, the test substance is not inhibitory to microorganisms.
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