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Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 Dec 1992 - 22 Apr 1993
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
Qualifier:
according to guideline
Guideline:
other: OECD 105
Version / remarks:
1981
GLP compliance:
yes
Medium:
n-octanol
Solubility:
196 g/L
Remarks on result:
other: CV 8.0%
Medium:
toluene
Solubility:
813 g/L
Remarks on result:
other: CV 4.7%
Medium:
methanol
Solubility:
207 g/L
Remarks on result:
other: CV 22.5%
Medium:
acetone
Solubility:
1 215 g/L
Remarks on result:
other: CV not determined
Medium:
ethyl acetate
Solubility:
847 g/L
Remarks on result:
other: CV 11.0%
Medium:
other: n-heptane
Solubility:
368 g/L
Remarks on result:
other: CV 21.7%
Medium:
other: dichloromethane
Solubility:
802 g/L
Remarks on result:
other: CV 9.2%
Details on results:
CV - coefficient of variation

No significant visual evidence of decomposition was noted over the duration of the testing. The stability of the test material in each solvent was demonstrated over a period of 5 days, with no apparent decomposition noted.

Description of key information

The following solubilities of the test substance in organic solvents were obtained at ambient temperature (OECD 116, OECD 105):

n-Octanol: 196 g/L

Toluene: 813 g/L

Methanol: 207 g.L

Acetone: 1215 g/L

Ethyl acetate: 847 g/L

n-Heptane: 368 g/L

Dichloromethane: 802 g/L

Key value for chemical safety assessment

Additional information