2-tert-butyl-4-methoxyphenol

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Remarks:

BULK DENSITY AND TAP DENSITY

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17/02/2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

other: standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.

Principles of method if other than guideline:

The bulk density and tap density was determined for the test substance following the standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

no

Type of method:

other: standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.

Specific details on test material used for the study:

- Name of test material: tert-butyl-4-methoxyphenol
- Common name: Phenol, (1,1-dimethylethyl)-4-methoxy-
- Molecular formula: C11H16O2
- Molecular weight: 180.2454 g/mol
- Smiles notation: COc1ccc(O)c(c1)C(C)(C)C
- InChI=1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3
- Substance type: Organic

Key result

Type:

bulk density

Density:

0.69 g/cm³

Temp.:

28.6 °C

Remarks on result:

other: No other detail available

Key result

Type:

tap density

Density:

0.69 g/cm³

Temp.:

28.6 °C

Remarks on result:

other: No other detail available

TEST DESCRIPTION AND RESULTS

Method Details		Observations	Remarks if, any
Guideline	“Test methods: Bulk density and tapped density of powders”recommended inThe International Pharmacopoeia, Fourth Edition, 2014[1]
Principle of method	Bulk and Tap densities are determined by measuring the volume of a known mass of powder into a graduated cylinder without and after tapping, respectively.
Method	Measurement in a Graduated Cylinder and Bulk Density Apparatus
Test temperature (°C)	-	28.6^oC
Weight (mass) of test substance (g)	m	20 gm
Volume of test substance in cylinder without tapping (ml)	v	29 ml
Volume of test substance in cylinder after tapping (ml)	v1	29 ml

 

CALCULATIONS:

Parameters	Details	Calculated Values (RESULT)
Bulk Density of test substance (g/cm^3)	= m     v	0.6896 gm/cm^3
Tap density of test substance (g/cm^3)	= m     v1	0.6896 gm/cm^3

 

Conclusions:

The bulk density and tap density was determined for the test substance following the standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.The bulk density was determine to be 0.6896 g/cm3 and the tap density was observed to be 0.6896 g/cm3 at 28.6 °C.

Executive summary:

The bulk density and tap density was determined for the test substance following the standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.The bulk density was determine to be 0.6896 g/cm³ and the tap density was observed to be 0.6896 g/cm³ at 28.6 °C.

Description of key information

The bulk density and tap density was determined for the test substance following the standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.The bulk density was determine to be 0.6896 g/cm³and the tap density was observed to be 0.6896 g/cm³at 28.6 °C.

Additional information

The bulk density and tap density was determined for the test substance following the standard method recommended in the International Pharmacopoeia, fourth Edition, 2014.The bulk density was determine to be 0.6896 g/cm³and the tap density was observed to be 0.6896 g/cm³at 28.6 °C.