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Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2021
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
yes (incl. QA statement)
Dissociating properties:
not determined
Remarks on result:
not determinable because of methodological limitations
Conclusions:
The dissociation constant of the test item should be determined according to the European Commission Regulation (EC) No. 2017/735, A.25 and according to the OECD test guideline 112. Despite adding water miscible organic solvents the solubility of the test item was too low for the determination of dissociation constants.
Executive summary:

The dissociation constant of the test item should be determined according to the European Commission Regulation (EC) No. 2017/735, A.25 and according to the OECD test guideline 112. Despite adding water miscible organic solvents the solubility of the test item was too low for the determination of dissociation constants.

Description of key information

The dissociation constant of the test item should be determined according to the European Commission Regulation (EC) No. 2017/735, A.25 and according to the OECD test guideline 112. Despite adding water miscible organic solvents the solubility of the test item was too low for the determination of dissociation constants.

Key value for chemical safety assessment

Additional information