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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Pow at pH 2 and 7 >1.6 x 107, which corresponds with a log Pow of > 7.2; OECD 117, EU Method A.8 and EPA OPPTS 830.7570
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 7.2
- at the temperature of:
- 35 °C
Additional information
The partition coefficient of the test material was investigated in accordance with the standardised guidelines OECD 117, EU Method A.8 and EPA OPPTS 830.7570 under GLP conditions using the HPLC method. The study was awarded a reliability score of 1 in accordance with the principles for assessing data quality set forth by Klimisch et al. (1997).
The HPLC method at pH 2 and 7 was used to estimate the partition coefficient of the organic components of the test material. Quantification was based on the organic anionic part of the test material. Solutions of a reference material and the test material were analysed. Based on the retention times of the compounds the Pow and log Pow value of the test material was determined.
At pH 2, several test material peaks were observed in the chromatogram of the test solution. Two peaks with a total relative peak area of 0.5 % had a retention time shorter than the reference material 4,4’-DDT and 29 peaks with a total relative peak area of 99.5 % had a retention time longer than the reference material benzo[ghi]perylene. Hence, it was concluded that the log Pow was < 6.5 (Pow < 3.2 x 106) for 0.5 % of the test material and > 7.2 (Pow > 1.6 x 107) for 95.5 % of the test material.
At pH 7, several test material peaks were observed in the chromatogram of the test solution. 28 peaks with a total relative peak area of 6.2 % had a retention time shorter than the reference material 4,4’-DDT, 8 peaks with a total relative peak area of 24.3 % had a retention time between the reference materials 4,4’-DDT and benzo[ghi]perylene, and 38 peaks with a retention time longer than the reference material benzo[ghi]perylene. Hence, it was concluded that the log Pow of test material was < 6.5 (Pow < 3.2 x 106) for 6.5 % of the test material, between 6.5 and 7.2 (Pow 3.2 x 106 to 1.6 x 107) for 24.3 % of the test material, and > 7.2 (Pow > 1.6 x 107) for 69.5 % of the test material.
Under the conditions of this study, the Pow of the test material at pH 2 and 7 was >1.6 x 107, which corresponds with a log Pow of > 7.2.
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