Reaction mass of (((1,3-phenylenebis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) and (1,3-phenylenebis(oxy))bis(propane-3,1-diyl) bis(2-methylacrylate) and 3-(3-(2-(2-(methacryloyloxy)ethoxy)ethoxy)phenoxy)propyl methacrylaterate

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

experimental study planned

Justification for type of information:

NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out: DiBrÖRMA

CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies: short-term toxicity to aquatic invertebrates
- Available non-GLP studies: None
- Historical human/control data: None
- (Q)SAR: ECOSAR v1.11 is of limited reliability in predicting chronic toxicity. Estimated chronic values are similar to experimentally-determined water solubility limits for the three major congeners. Toxicity cannot be excluded based on model results. It should be noted that Episuite software overestimates log Kow and underestimates water solubility. User inputs for these parameters reduce but do not eliminate predicted toxicity values.
- In vitro methods: None
- Weight of evidence: None
- Grouping and read-across: None
- Substance-tailored exposure driven testing: Not applicable

CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
As per column 2 of Annex VII, long-term aquatic toxicity testing on Daphnia shall be considered if the substance is poorly water soluble. No toxicity was observed in a short-term test on Daphnia. The major constituents have water solubilities ranging from 0.0422 mg/L to 0.292 mg/L. The corresponding structures have log Kows ranging from 5.36 down to 4.77. No bioaccumulation is expected due to rapid metabolism of the acrylate groups, as indicated by a QSAR model (Catalogic) of BCF. Little degradation was seen in a test of ready biodegradability.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 211 (Daphnia magna Reproduction Test)

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of (((1,3-phenylenebis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) and (1,3-phenylenebis(oxy))bis(propane-3,1-diyl) bis(2-methylacrylate) and 3-(3-(2-(2-(methacryloyloxy)ethoxy)ethoxy)phenoxy)propyl methacrylaterate

EC Number:

944-271-1

Cas Number:

2305048-54-6

Molecular formula:

not applicable for multi-constituent.

IUPAC Name:

Reaction mass of (((1,3-phenylenebis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) and (1,3-phenylenebis(oxy))bis(propane-3,1-diyl) bis(2-methylacrylate) and 3-(3-(2-(2-(methacryloyloxy)ethoxy)ethoxy)phenoxy)propyl methacrylaterate