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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April - July, 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspected on 17-18 March 2008; Signed on 23 June 2008
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: Givaudan Suisse SA / LDP0800001
- Expiration date of the lot/batch: 01 May 2010
- Physical appearance: colourless liquid
Key result
Water solubility:
14 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
7
Remarks on result:
other: in pure water
Water solubility:
14.2 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
8
Remarks on result:
other: in ISO-medium

TEST RESULTS

In a preliminary test 100.4 mg of the substance where added to 100 ml of water, and stirred. After 24 hours the substance had not dissolved. Therefore, the solubility in water is below 1 g/L.

 

Table 4.8/1: Solubility if test item

Contact time (days)

7

13

16

20

23

Concentration (mg/L)

 

 

 

 

 

Flask A

14.9

15.1

14.7

13.7

14.3

Flask B

13.2

14.5

14.1

14.3

13.1

ISO medium (average)

14.0

14.8

14.4

14.0

13.7

Flask C

12.7

13.4

14.1

15.5

14.0

Flask D

11.4

14.4

14.9

15.3

14.3

Water (average)

12.1

13.9

14.5

15.4

14.1

All tabulated values represent rounded-off results obtained by calculations based on the exact raw data.

The pH values of the solutions in double-distilled water at the end of the test were all approximately 7. The pH value of the solution in reconstituted water at the end of the experiment was 8.

They were measured with indicator paper because pH measurements with a glass electrode in a high electrical resistivity medium (double-distilled water) are not reliable.

Conclusions:
The solubility of test item in pure water and in reconstituted water according to ISO 6341 was determined according to the OECD Guideline No. 105 (flask method).

In water, Solubility of test item in water at 20°C is 14.0 mg/L.

ln lSO-medium, solubility of test item in ISO-medium at 20°C is 14.2 mg/L.
Executive summary:

The solubility of test item in pure water and in reconstituted water according to ISO 6341 was determined according to the OECD Guideline No. 105 (flask method).


In water, Solubility of test item in water at 20°C is 14.0 mg/L.


ln lSO-medium, solubility of test item in ISO-medium at 20°C is 14.2 mg/L.

Description of key information

The water solubility of test item was determined according to OCED 105 guideline using the flask method .


The result is 14 mg/L at 20°C and pH 7.

Key value for chemical safety assessment

Water solubility:
14 mg/L
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD method and under GLP, is available. It is considered as a key study.