Registration Dossier
Registration Dossier
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EC number: 814-970-5 | CAS number: 852620-97-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/03 to 17/03/2021
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 1-Methyl-1-propylpyrrolidinium Bis(fluorosulfonyl)imide
- EC Number:
- 922-377-9
- Cas Number:
- 852620-97-4
- Molecular formula:
- C8H18F2N2O4S2
- IUPAC Name:
- 1-Methyl-1-propylpyrrolidinium Bis(fluorosulfonyl)imide
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Doses:
- 300- 2000mg/kg bw/day
- No. of animals per sex per dose:
- 6 at the dose of 300mg/kg bw/day
3 at the dose of 2000mg/kg bw/day
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In conclusion, the LD50 of the test item N-propyl-N-methylpyrrolidinium bis(fluorosulfonyl)imide is higher than 300mg/kg bw/day and lower than 2000mg/kg bw/day by oral route in the rat. In accordance with OCDE Guideline 423, the LD50 cut-off of the test item may be considered as 500mg/kg bw/day by oral route in the rat. According to the criteria for classification, packaging and labelling of dangerous substances and preparations in accordance with the Regulation EC No 1272/2008, the test item has to be classified in category 4. The signal word "Warning" and hazard statement H302 "Harmful if swallowed" are required.
- Executive summary:
In conclusion, the LD50 of the test item N-propyl-N-methylpyrrolidinium bis(fluorosulfonyl)imide is higher than 300mg/kg bw/day and lower than 2000mg/kg bw/day by oral route in the rat. In accordance with OCDE Guideline 423, the LD50 cut-off of the test item may be considered as 500mg/kg bw/day by oral route in the rat. According to the criteria for classification, packaging and labelling of dangerous substances and preparations in accordance with the Regulation EC No 1272/2008, the test item has to be classified in category 4. The signal word "Warning" and hazard statement H302 "Harmful if swallowed" are required.
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