Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The BCF 28 days was <61 and ≤ 53 L/kg at the concentration of 0.02 and 0.2 µg/L, respectively. Pergafast 425 was not considered to be bioaccumulative since the BCF is < 2000 L/kg.
Key value for chemical safety assessment
Additional information
A bioconcentration study was conducted according to OECD guideline 305-I: aqueous exposure bioconcentration fish test and GLP principles. The fish were exposed to a concentration of 0.02 and 0.2 µg/L and a solvent control. Samples of the test water and fish were taken on several time points during the uptake phase to determine the stability of the test item in the water and the concentration of test item in fish tissue. At the exposure concentration of 0.02 µg/L, the concentration of test item in fish tissue was below the LOQ (1.3 ng/g fish). At the concentration of 0.2 µg/L, the average test item concentrations were over ±20% in the test fish samples taken at day 14, 20, 26 and 28. The average concentrations in fish tissue were 5.9, 6.6, 11, 6.0 ng/g fish on day 14, 20, 26 and 28, respectively. No steady state BCF could be determined since the concentration in fish sample was below the LOQ or the variation of the test item concentration was >20%. The BCF after 28 day was set to be <61 L/kg and ≤ 53 L/kg at the nominal concentration of 0.02 and 0.2 µg/L, respectively. Since the BCF of the test item was below 100 L/kg, a depuration phase was not conducted and the kinetic BCF values and the half life time values were not determined. Pergafast 425 was not considered to be bioaccumulative since the BCF is < 2000 L/kg. The validity criteria of the study were met and therefore the study is considered to be valid without restrictions.
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