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Administrative data

Description of key information

NOAEL (oral, rat, 90 days) = 347 mg/kg bw/day

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
NOAEL
347 mg/kg bw/day
Study duration:
subchronic
Species:
rat

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The evaluation of the toxicity of the substance after a repeated exposure is done by use of data on the similar substances. Justification for Read Across is given in Section 13 of IUCLID.

The available information on the similar substances is presented in the attached document in the summary.

Justification for classification or non-classification

For the classification of the substance as STOT-RE the dose in which significant toxic effects are observed is taken into consideration. If this dose is in the range of the guidance values indicated in the CLP Regulation (EC) No. 1272/2008 Annex I: 3.9.2.9.6 and Annex I: 3.9.2.9.7 then the substance is classified in Category 1 or Category 2 respectively.

Based on the available repeated dose toxicity studies, the substance is not classified for STOT-RE according to the CLP Regulation (EC) No. 1272/2008.