Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 953-378-2 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The registered substance is an uvcb, each constituent are predicted to be not bioaccumulable (BCF < 2000 L/kg).
Considering a worst case approach, the predicted value for alkylamines constituents remains the highest predicted BCF value. Therefore the BCF = 173 L/kg was used for regulatory purpose to define the bioaccumulation potential of the registered uvcb (EC 953-378-2).
Key value for chemical safety assessment
- BCF (aquatic species):
- 173 L/kg ww
Additional information
The registered substance is a salt (EC 953-378-2) constituted by both parts (primary alkylamines and alkylbenzene sulfonic acid) are generally present with a 1:1 ratio. Bioaccumulation potential was estimated on both constituents which constitute the registered salt.
Regarding the Primary Alkylamine part, the most suitable approach to derive a BCF is the ADME Model of Arnot and Gobas (2003) for the unprotonated C16 amine. C16 amine is a model compound for the Primary alkyl amines. Therefore it is proposed to use for the Primary alkyl amines a BCF of 173 L/kg as estimated by the ADME Model of Arnot & Gobas (2003) on basis of a Weight of Evidence.
Regarding the C10-13 alkylbenzenesulfonic acid part, the linear alkylbenzene sulfonate compound (C13) has been considered to predict the BCF and constitute a worst-case approach. QSAR estimation using the BCFBAF v3.01 of the EPISUITE 4.1 indicate that the BCF in fish of the C13 linear alkylbenzene sulfonate acid is 70.8 L/kg ww. The (Q)SAR is valid and was applied to a chemical falling within its applicability domain.
This predicted value on the C13 Alkylbenzenesulphonate was supported by experimental studies available on similar substance:
- Freitag D, 1982 (publication similar to OECD 305, BCF = 130 L/kg, 3 days, Na n-Dodecylbenzene sulfonate (N salt), Leuciscus idus melanotus)
- Versteeg, 2003 (publication similar to OECD 305, BCF = 36 to 119 L/kg, 32 days, C12-LAS mixed isomer (97% of C12) Pimephales promelas & Ictalurus punctatus)
Considering a worst case approach, the predicted value for alkylamines constituents remains the highest predicted BCF value. Therefore the BCF = 173 L/kg was used for regulatory purpose to define the bioaccumulation potential of the registered substance (EC 953-378-2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
