Registration Dossier
Registration Dossier
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EC number: 619-511-0 | CAS number: 141573-96-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- Principles of method if other than guideline:
- In vitro test for corrosivity on reconstructed human epidermis EST-1000.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride
- EC Number:
- 619-511-0
- Cas Number:
- 141573-96-8
- Molecular formula:
- C6H5ClF2N2O
- IUPAC Name:
- 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride
Constituent 1
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- mean value of 3 tissues
- Run / experiment:
- 3 min exposure
- Value:
- 73.58
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks:
- The reliability of the test method was confirmed prior to the experimental study by interlaboratory validation.
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- mean value of 3 tissues
- Run / experiment:
- 60 min exposure
- Value:
- 1.51
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks:
- The reliability of the test method was confirmed prior to the experimental study by interlaboratory validation.
Any other information on results incl. tables
No scores on irritation parameters can be provided, as the study is an in vitro study using reconstructed human epidermis.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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