Registration Dossier
Registration Dossier
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EC number: 402-730-9 | CAS number: 54914-85-1 KS-232
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- other: reference to SNIF-file
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-bis(3-methylphenoxy)ethane
- EC Number:
- 402-730-9
- EC Name:
- 1,2-bis(3-methylphenoxy)ethane
- Cas Number:
- 54914-85-1
- Molecular formula:
- C16H18O2
- IUPAC Name:
- 1-methyl-3-[2-(3-methylphenoxy)ethoxy]benzene
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact skin
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg - Duration of treatment / exposure:
- 4 h
- Observation period:
- 76 h
- Number of animals:
- 6
- Details on study design:
- Test sites were covered with a watch glass of 1 inch diameter to ensure good skin contact.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Remarks:
- intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Remarks:
- intact skin
- Irritant / corrosive response data:
- Abraded skin:
- mean scores for erythema and oedema respecitvely for all animals (4/28/52/76 h):
0.3-0/0.2-0/0.2-0/0-0
Maximum score for one animal 1-0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No skin irritation was observed in a study conduceted according to OECD 404 in rabbits. After an observation period of 76 hours, for intact skin all scores for erythema and edema were 0.
For abraded skin very slight erythema with a maximum score of 1 in one animal was observed. Effects were fully reversible within 76 hours.
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