Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 951-974-7 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
35-day NOEC based on mortality and sub-lethal effects: 0.686 mg/L
5-day NOEC based on number hatched: >9.76 mg/L (effective); read-across MDEA-Esterquat C16-18 and C18 unsatd.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.686 mg/L
Additional information
No experimental data are available for the target substance MDEA-Esterquat C18 satd. However, a long-term toxicity study in freshwater fish is available for the closely related source substance MDEA-Esterquat C16 -18 and C18 unsatd. A justification for read-across is given in the general endpoint summary Aquatic toxicity.
The 35-day chronic toxicity of MDEA-Esterquat C16-18 and C18 unsatd. to early life stages of Fathead minnow, Pimephales promelas, was studied under flow-through conditions using river water, according to US EPA TSCA, 40 CFR, Part 797.1600. Fertililized eggs (25 eggs, reduced to 15 fry after hatch) were exposed to a control and measured concentrations of 0.686, 1.41, 2.68, 5.30 and 9.76 mg/L as total activity by LSC. The test system was maintained at 25 +/- 1°C and a pH of 8.0 (7.7 to 8.3). The 35 -day NOEC values, based on mortality (post-fry reduction) and sub-lethal effects (length and weight) were 0.686 mg/L. The 5-day NOEC based on number hatched was >9.76 mg/L. Although the post-fry reduction survival did not monotonically decrease with exposure concentration, a NOEC of 0.686 mg/L could statistically be determined. Although survival in one control chamber prior to fry reduction and one control chamber at test termination was <70%, the NOEC of 0.686 mg/L met validity criteria of survival in each chamber of >70%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
