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EC number: 951-974-7 | CAS number: -
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- Aquatic toxicity
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- Short-term toxicity to fish
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Zebrafish (Danio rerio): 96 h LC50=5.2 mg/L (nominal; 95% C.I.: 4.4 to 6.3 mg/L); OECD Guideline 203; RL2, GLP; read-across MDEA-Esterquat C16-18, C18 unsatd.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5.2 mg/L
Additional information
No experimental data are available for the target substance MDEA-Esterquat C18 satd. However, short-term toxicity studies in freshwater fish are available for the closely related source substances MDEA-Esterquat C16 -18 and C18 unsatd., MDIPA Esterquat C16-18 and C18 unsatd and MDIPA Esterquat C18 unsatd. A justification for read-across is given in the general endpoint summary Aquatic toxicity.
In a 96 h acute toxicity study according to OECD TG 203, Zebra fish (Danio rerio), were exposed to the structurally similar source substance MDEA-Esterquat C16-18 and C18 unsatd. at nominal concentrations of 0, 1.0, 1.6, 2.5, 4.0, 6.3 and 10 mg/L under static conditions. The nominal 96 h LC50 value based on mortality was 5.2 mg/L (95% C.I.: 4.4 to 6.3 mg/L). Mortality occurred in the first 48 h. After this time, seemingly moribund organisms recovered. Within the first 48 h the test solutions at concentrations of 2.5, 4.0, 6.3, and 10 mg/L showed a Tyndall effect. The intensity increased with increasing concentrations. Precipitates were observed on the bottom of the test aquarium in the exposure concentrations of 2.5 to 10 mg/L 48 h after preparation of the test solution. These observations suggest that mortality is most likely a physical and not a toxic effect due to the undissolved particles in the water phase. 5 additional fish were added to the 10.0 mg/L solution after 48 h (the time the precipitates were observed). The animals survived until test termination which supports the assumption of physical effects.
Similar results were obtained with the closely related read-across substance MDIPA Esterquat C16-18 and C18 unsatd and MDIPA Esterquat C18 unsatd.:
In a 96-h acute toxicity study according to OECD guideline 203, adopted 17 July 1992, Carp (Cyprinus carpio, Teleostei, Cyprinidae) Linnaeus, 1758 were exposed to MDIPA Esterquat C18 unsatd. (100% a.i) at nominal concentrations of 0 (control), 0.10, 0.32,1.0, 3.2 and 10 mg/L under semi-static conditions in the presence of 4 mg humic acid per litre (i.e. 2-4 mg dissolved organic carbon per litre).
Measured test item concentrations were in agreement with nominal (90-93%). These concentrations remained stable during both refreshment periods (87-90% of initial). Given these results, effect parameters can be based on the nominal test concentrations.
No mortality or other clinical effect was observed at any of the test concentrations and the control during the 96-hour test period.The 96-h LC50 was >10 mg a.i./L.
The 96–hr-acute toxicity of MDIPA-Esterquat C16-18 and C18 unsatd. to eggs of Danio rerio was studied under semi-static conditions according to guideline OECD guideline 236 (2013). Eggs were exposed to control and test chemical at analytically determined geometric mean concentrations of 0, 0.986, 1.90, 4.15, 8.05, and 16.0 mg/L under semi-static conditions with daily renewal. Analytics and all observations were made daily.
After 96 hours, the number of coagulated embryos in the 0.986, 1.90, 4.15, 8.05, and 16.0 mg/L test substance treatments was 0, 1, 0, 3, and 13 respectively, out of an initial 20 embryos.
None of the embryos in the control or test substance treatments lacked somites throughout the test, with the exception of two embryos in the 8.05 mg/L test substance treatment at 24 hours, and all embryos in the control and test substance treatments exhibited detached tails after 96 hours.
Out of an initial 24 embryos, one embryo had no visible heartbeat in the control at 48 hours. Two embryos in the 8.05 mg/L treatment and eight embryos in the 16.0 mg/L treatment lacked heartbeats after 48 hours; three embryos in the 16.0 mg/L lacked heartbeats after 72 hours; and one embryo lacked a heartbeat in the 8.05 mg/L treatment after 96 hours
The hatching rate after 96 hours was 96% in the control and 100, 90, 95, 55, and 25% in the 0.986, 1.90, 4.15, 8.05, and 16.0 mg/L test treatments, respectively.
The 96-hour LC50 was estimated to be 11.7 mg/L with 95% confidence limits of 9.91 and 13.8 mg/L.
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