2H-Pyran, tetrahydro-3-(phenylmethyl)-

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April 28 to December 01, 2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method. No deviation affected the quality of the study. The substance is considered to be adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

1992

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

-4.1 °C

Decomposition:

no

Sublimation:

no

Three DSC analysis were performed. According to the given information, the temperature range for the investigation of the melting point was fixed in a range below 0°C.

In each thermogram two signals were observed. An exothermic signal below -10°C and an endothermic signal above -10°C. The endothermic signals were evaluated and the following characteristic data were determined:

sample	weight	onset temperature	peak temperature
1	4.126 mg	- 4.05°C	-0.36°C
2	8.734 mg	- 4.21°C	0.00 °C
3	5.044 mg	- 3.94°C	-0.82°C
mean		- 4.07°C

For proving of the melting point, the mass of test item before and after performing DSC analysis was measured, and no significant mass difference was observed. Furthermore, the thermal stability of the samples used were checked by a second run of the first sample, which showed the same thermal signals as in the first run. According to these facts it can be concluded that the endothermic signals are resulted from phase transition from the solid to the liquid state (i.e. melting point).

Executive summary:

The test substance was first cooled down to -100°C, then the melting point was determined according to EU A.1 guideline, using Differential Scanning Calorimetry method.

Three main runs were performed, under nitrogen flow; onset results were found consistent, so the mean final temperature was retained.

The melting temperature of test substance has been determined to be -4.1 °C.

Description of key information

Experimental melting point (i.e. transition from solid to liquid) under N2 = -4.1°C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

-4.1 °C

Additional information

A fully reliable experimental study, conducted according to a recognized EC method, and under GLP, is available.

It is considered as a key study, and the result is retained as key data.