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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 January - 3 February 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Version / remarks:
1981
Deviations:
no
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
EC Number:
222-468-7
EC Name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
Cas Number:
3483-12-3
Molecular formula:
C4H10O2S2
IUPAC Name:
1,4-disulfanylbutane-2,3-diol
Specific details on test material used for the study:
Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen

Results and discussion

Particle sizeopen allclose all
Key result
Percentile:
D10
Mean:
20.5 µm
St. dev.:
0.48
Remarks on result:
other: Average result calculated from the results of two test series
Key result
Percentile:
D50
Mean:
556.9 µm
St. dev.:
0.78
Remarks on result:
other: Average result calculated from the results of two test series
Key result
Percentile:
D90
Mean:
1 147.1 µm
St. dev.:
0.41
Remarks on result:
other: Average result calculated from the results of two test series

Any other information on results incl. tables

Light Microscopy

At 5x and 20x magnifications bigger particles can be observed. Examining the 50x magnification, the test item consists of crystalline particles.

 Particle Size Distribution

Two test series of 3 measurements each were performed with the test item.

Test series 1:

 Percentile

 Particle size (µm)

 Standard deviation

 D10

 21.0

 0.96

 D50

 556.1

 3.79

 D90

 1147.5

 3.64

Test series 2:

 Percentile

 Particle size (µm)

 Standard deviation

 D10

 20.0

 1.13

 D50

 557.6

 7.88

 D90

 1146.7

 7.83

Applicant's summary and conclusion

Conclusions:
The test item 1,4 Dithiothreitol (CAS no. 3483-12-3) has a coarse fraction > 2000 µm of 29.2 wt.-%. The fine fraction has a median particle size of D50 = 556.9 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline 830.7520 (1996).
Executive summary:

The test item1,4-Dithiothreitol (CAS no.3483-12-3) has a coarse fraction > 2000 µm of 29.2 wt.-%. The fine fraction has a median particle size of D50 = 556.9 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline 830.7520 (1996).