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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
thermal stability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 January - 21 February 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)
Version / remarks:
1981
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
EC Number:
222-468-7
EC Name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
Cas Number:
3483-12-3
Molecular formula:
C4H10O2S2
IUPAC Name:
1,4-disulfanylbutane-2,3-diol
Specific details on test material used for the study:
Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen

Results and discussion

For thermal stability study

Test substance thermally stable:
yes
Operating temperatureopen allclose all
Key result
Operating temp.:
ca. 30 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
ca. 290 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
ca. 300 °C
Remarks on result:
other: exothermic effect
Sublimation:
not determined
Transformation products:
not specified

Any other information on results incl. tables

The test item in closed glass crucibles showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290 °C, which was directly followed by an exothermic effect starting at a temperature of 300 °Cwith an average energy release of -50 J/g.

Results of the DSC-measurement

No.   Sample weight/mg Onset/°C   Range of Effect/°C
 PN19027  4.23

 30

290

300

+120 (endothermic)
+30 (endothermic) 

-60 (exothermic)
 PN19050  7.50

 30

290

300

 +100 (endothermic)
+30 (endothermic) 

-40 (exothermic)

Applicant's summary and conclusion

Conclusions:
The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290°C, which was directly followed by an exothermic effect starting at a temperature of 300°C with an average energy release of -50 J/g.
Executive summary:

The test item1,4-Dithiothreitol (CAS no. 3483-12-3) showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290°C, which was directly followed by an exothermic effect starting at a temperature of 300°C with an average energy release of -50 J/g.