(R*,R*)-1,4-dimercaptobutane-2,3-diol

Explosiveness

Administrative data

Endpoint:

explosive properties of explosives

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties

Justification for type of information:

The decomposition energy of the substance is less than 500J/g as determined by DSC-Measurement.
See further information in the cross-ref.

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

thermal stability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30 January - 21 February 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

Version / remarks:

1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen

Test substance thermally stable:

yes

Key result

Operating temp.:

ca. 30 °C

Remarks on result:

other: endothermic effect

Key result

Operating temp.:

ca. 290 °C

Remarks on result:

other: endothermic effect

Key result

Operating temp.:

ca. 300 °C

Remarks on result:

other: exothermic effect

Sublimation:

not determined

Transformation products:

not specified

The test item in closed glass crucibles showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290 °C, which was directly followed by an exothermic effect starting at a temperature of 300 °Cwith an average energy release of -50 J/g.

Results of the DSC-measurement

No.	Sample weight/mg	Onset/°C	Range of Effect/°C
PN19027	4.23	30 290 300	+120 (endothermic) +30 (endothermic)  -60 (exothermic)
PN19050	7.50	30 290 300	+100 (endothermic) +30 (endothermic)  -40 (exothermic)

Conclusions:

The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290°C, which was directly followed by an exothermic effect starting at a temperature of 300°C with an average energy release of -50 J/g.

Executive summary:

The test item1,4-Dithiothreitol (CAS no. 3483-12-3) showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290°C, which was directly followed by an exothermic effect starting at a temperature of 300°C with an average energy release of -50 J/g.