Registration Dossier
Registration Dossier
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Reaction mass of lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]naphthalene-2,7-disulfonate and lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-{[4-(vinylsulfonyl)phenyl]diazenyl}naphthalene-2,7-disulfonate
EC number: 941-533-7 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 13 October, 1986 to 28 October, 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- -4.99
- Temp.:
- 21.5 °C
- Remarks on result:
- other: Octanol concentration: 0.013-0.015 x 10-3 mg/ml; water concentration: 1.3674 mg/ml
- Type:
- log Pow
- Partition coefficient:
- < -4.82
- Temp.:
- 21.5 °C
- Remarks on result:
- other: Octanol concentration: <0.001 x 10-5 mg/ml; water concentration: 0.65 mg/ml
- Type:
- log Pow
- Partition coefficient:
- < -4.5
- Temp.:
- 21.5 °C
- Remarks on result:
- other: Octanol concentration: <0.01 x 10-3 mg/ml; water concentration: 0.31 mg/ml
- Conclusions:
- Under the study conditions, the log Pow of the test substance was determined to be -4.99 at 21.5°C.
- Executive summary:
A study was conducted to determine the n-octanol/water partition coefficient of the test substance according to EU Method A.8, in compliance with GLP. The partition coefficient of the test substance was determined according to the HPLC method. Samples were prepared in aqueous and n-octanol phases. After sample preparation, the concentration of the test substance was determined using UV-VIS sprectrometry. The log Pow values varied between <-4.5 and -4.99. Under the study conditions, the log Pow of the test substance was determined to be -4.99 at 21.5°C (Hellbusch, 1986).
Reference
Because the substance is a salt, the log Kow is, as expected, concentration-dependent.
Description of key information
The n-octanol/water partition coefficient was determined according to EU Method A.8 (Hellbusch, 1986).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -4.99
- at the temperature of:
- 21.5 °C
Additional information
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