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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-12-15 to 2009-03-23
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation affected the quality of the study. However, some experimental details are missing.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
27th July 1995
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Council Regulation (EC) No 440/2008 of 30 May 2008
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspected on 14 September 2010 / Signed on 07 February 2011
Type of method:
flask method
Specific details on test material used for the study:
Storage condition of test material: room temperature.
Key result
Water solubility:
999 µg/L
Conc. based on:
test mat.
Loading of aqueous phase:
110 mg/L
Incubation duration:
>= 24 - <= 144 h
Temp.:
20 °C
Remarks on result:
other: pH was not recorded

Individual results are shown in the following table.

 Stirring time* Concentration [μg/L]  Mean -15%  Mean +15%
 at 20°C [h]  vessel 1  vessel 2  vessel 3  mean  [μg/L]  [μg/L]
 24  (796.2)** 971.5  923.3 947.4 805.3  1089.5
 48 916.9  1048.9  1061.9 1009.3 857.9  1160.6 
 72 1001.1  960.1  1042.7 1001.3 851.1  1151.5 
 144 1101.8  953.8  1006.7 1020.8 867.7  1173.9 
Overall mean (calc. from single values):  999.0    

*after initial stirring time of 24 h at 30°C ** outlier (value not considered)

The results obtained at the 4 sampling times were in agreement (did not differ by more than 15 %). No tendency to increasing values with increasing equilibration times was observed. So the equilibration times used were long enough according to the test guideline and the test was satisfactory.

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
Executive summary:

The water solubility of the test substance was measured according to the OECD 105/EU A6 guideline, flask method.

Triplicate vessels were incubated with ca 110 mg/L at 30°C for 24h, then equilibrated at 20°C for 24 to 144h, with slow-stirring. Samples were extracted and analysed by GC-AED, calibrated with 6 standard solutions and an internal standard substance. Results were consistent (repeatability < 15%), so equilibrium was considered to be reached.

The water solubility (mean of 4 sampling times) was determined as 0.999 mg/L at 20°C.

Description of key information

The substance is considered to be slightly soluble in water.

Key value for chemical safety assessment

Water solubility:
0.999 mg/L
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Despite restrictions on experimental details, it is considered as a key study, and the result is retained as key data.