(4aR*, 8aR*)-1-bromo-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef] [2]benzazepin-6-one hydrochloride (1:1)

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001-11-15 to 2002-01-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

no

Remarks:

The testing facility indicated that the protocol was followed without deviation.

GLP compliance:

yes (incl. QA statement)

Remarks:

GLP certificates from the SWISS GLP Monitoring Authorities

Specific details on test material used for the study:

- Batch n°: RT002102G4A311
- Analytical purity: 99.4%
- Expiration date: 25 March 2002
- Storage condition: at room temperature

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

T002102 could not be ignited with a flame during the preliminary test (contact time of about 2 minutes). In contact with the ignition source, T002102 carbonized. The test item did not melt. There was no smoke or soot observed, therefore no main test was performed.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

In conclusion, T002102 is not ''highly flammable'' according to the criteria as described in the guidance.

Reference 2

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

the study does not need to be conducted because the substance is known to be soluble in water to form a stable mixture

other:

Reference 3

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

other:

Reference 4

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

31 October - 03 November 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

- Batch n°: M16DB1211
- Analytical purity: 99.7% (base titration)
- Expiration date: 05 April 2017
- Storage condition: at room temperature

Key result

Test procedure:

100 mm sample cube at 140°C

Result:

negative outcome (no effect observed)

A negative result was obtained. No spontaneous ignition occurred and no exothermic effect of the test item was observed. It demonstrated that the test item is “not a self-heating substance”. According to the UN guideline, no further testing is required.

After the experiment, the consistency of the sample was unchanged, i.e. no reaction and/or decomposition of the test item was observed.

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the results of the UN N.4 test performed, the test item is considered ‘not self-heating’.

Description of key information

The flammability potential of the substance was determined in a GLP study according to test method EC A.10. Based on the criteria as outlined in the OECD Guideline, T002102 is not a "highly flammable" substance.

Furthermore, the substance is not considered to be pyrophoric or emit flammable gases in contact with water. Based on a GLP study according to the test method UN N.4 (K1, Reingruber, 2016), the test item was determined to be not a self-heating substance.

Key value for chemical safety assessment

Flammability:

not classified

Additional information

The flammability test was carried out under GLP conditions and according to the EC method A.10 without modifications, so therefore a Klimisch score 1 was assigned (reliable without restrictions). T002102 could not be ignited with a flame during the preliminary test (contact time of about 2 minutes). In contact with the ignition source, T002102 carbonized. The test item did not melt and there was no smoke or soot observed. The results from the A.10 test method indicate that a classification as a flammable solid does not apply (result: not highly flammable), therefore no more testing is necessary.

Justification for classification or non-classification

T002102 is not ''highly flammable'' according to the criteria as described in the guidance and therefore classification as flammable solid does not apply. The substance is also considered to be not pyrophoric or emit flammable gases in contact with water. Based on the negative outcome of the UN N.4 test, the substance is also determined to be not self-heating based on the criteria described in the guidance.