Fuels, diesel, co-processed with hydrocarbons derived from thermally cracked waste plastics

Specific investigations: other studies

Administrative data

Endpoint:

phototoxicity

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study is classified as reliable with restrictions because it is an acceptable, well-documented study report.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1990

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Undiluted test material was dosed at 0.3 mL/site, two test sites per animal. Single one hour exposure to test article, 10J/cm2 UV A exposure (5.6 hours). Observations were made at 30 minutes and 24, 48, and 72 hours post UV A exposure.

GLP compliance:

yes

Type of method:

in vivo

Endpoint addressed:

skin irritation / corrosion

Test material

Test material information

Constituent 1

Reference substance name:

Fuels, diesel

EC Number:

269-822-7

EC Name:

Fuels, diesel

Cas Number:

68334-30-5

IUPAC Name:

Fuels, diesel

Constituent 2

Reference substance name:

Naval distillate

IUPAC Name:

Naval distillate

Test material form:

other: low viscosity liquid hydrocarbon

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

female

Administration / exposure

Route of administration:

dermal

Vehicle:

unchanged (no vehicle)

Results and discussion

Details on results:

The mean scores (erythema plus oedema) for intact skin are detailed in the table of the results section. Based on the 24 and 72 hour scores, the irritation index for the test material is 5.4 and 2.1 for exposed and unexposed skin. The photo irritation index is 3.3.

Any other information on results incl. tables

Mean scores (erythema plus oedema) for intact skin sites. Score range from 0 -8, 0=no reaction, 8=severe

Exposed to UV A	24 hour	72 hour
1% Methoxypsoralen	6.6	5.8
Test material F-188	5.4	5.4
Not exposed to UV A
1% Methoxypsoralen	0.0	0.0
Test material F-188	2.0	2.2

Applicant's summary and conclusion

Conclusions:

Based on the 24 and 72 hour scores, the irritation index for thes test material is 5.4 and 2.1 for exposed and unexposed skin. The photoirritation index is 3.3. Based on the parameters of this study, the test article is a moderate photoirritant to the skin of albino rabbits.

Executive summary:

In a photoirritation study, 5 female New Zealand White rabbits were dosed with undiluted test material (Naval distillate) at 0.3 mL/site, two test sites per animal. Single one hour exposure to test article and 10J/cm2 UV A exposure (5.6 hours). Observations were made at 30 minutes and 24, 48, and 72 housr post UV A exposure.

Based on the 24 and 72 hour scores, the irritation index for thes test material is 5.4 and 2.1 for exposed and unexposed skin. The photoirritation index is 3.3. Based on the parameters of this study, the test article is a moderate photoirritant to the skin of albino rabbits.

This study received a Klimisch score of 2 and is classified as reliable with restrictions because it is an acceptable, well-documented study report.