Reaction products of triphenyl phosphite and isodecanol (1:1)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well document study, following standard protocols.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OTS 798.1175 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Phosphorous acid, diphenyl isodecyl ester

Molecular formula:

C22H31O3P

IUPAC Name:

Phosphorous acid, diphenyl isodecyl ester

Constituent 2

Reference substance name:

Triphenyl phosphite

EC Number:

202-908-4

EC Name:

Triphenyl phosphite

Cas Number:

101-02-0

Molecular formula:

C18H15O3P

IUPAC Name:

triphenyl phosphite

Constituent 3

Reference substance name:

Diisodecyl phenyl phosphite

EC Number:

247-098-3

EC Name:

Diisodecyl phenyl phosphite

Cas Number:

25550-98-5

Molecular formula:

C26H47O3P

IUPAC Name:

Reaction products of triphenyl phosphite and isodecanol (1:2)

Constituent 4

Reference substance name:

Grouped, low level constituents (1) - see description

Molecular formula:

C21H29O3P and C23H33O3P

IUPAC Name:

Grouped, low level constituents (1) - see description

Constituent 5

Reference substance name:

Grouped, low level constituents (2) - see description

Molecular formula:

N/A

IUPAC Name:

Grouped, low level constituents (2) - see description

Constituent 6

Reference substance name:

Triisodecyl phosphite

EC Number:

246-998-3

EC Name:

Triisodecyl phosphite

Cas Number:

25448-25-3

Molecular formula:

C30H63O3P

IUPAC Name:

Phosphorus acid, triisodecyl ester

Constituent 7

Reference substance name:

Grouped, low level constituents (3) - see description

Molecular formula:

N/A

IUPAC Name:

Grouped, low level constituents (3) - see description

Test material form:

liquid

Test animals

Species:

rat

Strain:

CD-1

Sex:

male/female

Details on test animals or test system and environmental conditions:

Rats were obtained from Charles River UK.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

Rats were deprived of food for 18 hours prior to treatment and for a further 4 hours after treatment. Doses were administered by gastric intubation. All doses were adjusted to maintain a constant volume of 40 mL/kg.

Doses:

0.43, 0.75, 1.31, 2.30, 4.00, 6.90, 12.00 g/kg

No. of animals per sex per dose:

5 male and 5 female

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

3 840 mg/kg bw

Based on:

test mat.

95% CL:

2 910 - 5 060

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

6 730 mg/kg bw

Based on:

test mat.

95% CL:

4 710 - 9 630

Mortality:

No mortality was seen at doses up to and including 2300 mg/kg. Mortality was seen in 1 female rat and 3 male rats at 4000 mg/kg. All males rats in the 6900 and 12,000 mg/kg doses died. Two female rats in the 6900 mg/kg dose died and all died at 12,000 mg/kg.

Clinical signs:

other: Some clinical observations were observed at doses starting at 2300 mg/kg and up including hypoactivity, piloerection, diarrhea, tremors, and prostration.

Applicant's summary and conclusion

Interpretation of results:

sligthly toxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The acute effects in this study were all seen at doses of 2300 mg/kg and higher. Mortaility was observed in doses 4000 mg/kg and higher. Such high doses would generally not be used in modern guideline studies.

Executive summary:

The LD50s were determined to be 3840 mg/kg for males and 6730 for females. These LD50 are well above the level for classification.