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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

TPP, an analog of DPDP, has been identified as a neurotoxicant in several high-dose acute studies. However, another close chemical analog diisodecyl phenyl phosphite (DDPP), showed limited neurtoxicty effects in a subchronic neurotoxicity study in hens where the NOAEL for neurtoxicity was 1000 mg/kg. A conservative NOAEL for this endpoint comes from the Tyl 2004 TPP repeat-dose study, which had an overall NOAEL of 15 mg/kg bw and included FOBs and neurotoxic evaluations.

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Dose descriptor:
NOAEL
15 mg/kg bw/day

Additional information

TPP, an analog of DPDP, has been identified as a neurotoxicant in several high-dose acute studies. However, another close chemical analog diisodecyl phenyl phosphite (DDPP), showed limited neurtoxicty effects in a subchronic study in hens where the NOAEL for neurtoxicity was 1000 mg/kg. Based on a comparison of endpoint data for the alkyl/phenyl phosphites, it is apparently that toxicity increases with the number of phenyl groups on the phosphite, with TPP (triphenyl) being the most toxic member of the class. Use of TPP data is felt to be the most conservative approach to characterising this endpoint for DPDP. The NOAEL comes from the Tyl 2004 TPP repeat-dose study, which had an overall NOAEL of 15 mg/kg bw and included neurotoxic and FOB evaluations.

Justification for classification or non-classification