Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
Summary information of human health hazard assessment of existing chemical substances (I)
Author:
Matsumoto, M.; Kobayashi, K.; Takahashi, M.; Hirata-Koizumi, M.; Ono, A.; Hirose, A.
Year:
2015
Bibliographic source:
Bull. Natl Inst. Health Sci., 133, 42-47

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Deviations:
not specified
GLP compliance:
not specified
Type of assay:
mammalian erythrocyte micronucleus test

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative
Remarks:
up to MTD
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
The test substance was negative up to the maximum tolerated dose (1000 mg/kg bw/day for 2 days) in mice. Based on these results, 1,3,5-triazine-2,4,6 (1H,3H,5H)-tritione was considered to be non-genotoxic in vivo.