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EC number: 439-730-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 05-06-2003 to 04-07- 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP study performed according to OECD TG 305
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- Deviations:
- yes
- Remarks:
- Longer exposure period - 28 days
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 305
- Principles of method if other than guideline:
- Longer exposure period (28 days)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals/frequency for test medium samples: days 7, 14, 21, 26, 28
- Sample storage conditions before analysis: no storage
- Details on sampling and analysis of test organisms and test media samples: Water: Extraction with CH2Cl2 with further HPLC analysis. - Vehicle:
- yes
- Details on test solutions:
- - Solubilising agent: Tween 80
- Concentration of the solubilising agent: 20 mg/L - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- - Weight: 2.82 g
- Length: 6.4 cm
- Lot: 30407
- Acclimatisation: 07.04.2003 - 29.05.2003 - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Hardness:
- 250 mg/L
- Test temperature:
- 24.6 °C
- pH:
- 7.1
- Dissolved oxygen:
- 7.3 mg/L
- Salinity:
- According to guideline
- Nominal and measured concentrations:
- Concentrations: 0.05 mg/L, 0.005 mg/L
- Reference substance (positive control):
- no
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.05 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 0.05 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of test organisms: no effects
- Behavioural abnormalities: no effects
- Observations on body length and weight: no effects
- Other biological observations: no effects
- Bound residues forming a plateau: none
- Mortality and/or behavioural abnormalities of control: none
- Loss of test substance during test period: none
- Results with vehicle control: no effects - Validity criteria fulfilled:
- yes
- Conclusions:
- The test item showed no toxic potential at concentrations at or above the water solubility. The NOEC was determined to be > 0.05 mg/L and thus higher than the limit of water solubility.
- Executive summary:
The study was performed according to the OECD Guideline for Testing of Chemicals 305 (Bioconcentration: Flow-through Fish Test) adopted on June 14, 1996 using two test item concentrations for exposure to Cyprinus carpio. The purpose of this study was to determine the bioconcentration potential of the test material in fish under flow-through conditions. During the GLP compliant test the lethal and other effects in fish were determined during the exposure period of 28 days. Two environmental concentrations of the test item were used in this study - 0.05 and 0.005 mg/L. The exposure concentration was maintained using Tween 80 as solubiliser. The concentrations were verified analytically using a HPLC method with UV detection. There was no mortality and no signs of toxicity detected throughout the study in any dose group up to 28 days of exposure. The test item showed no relevant toxic potential at concentrations above the limit of the water solubility. The NOEC at 14-d and 28-d exposure was determined to be >0.05 mg/L.
Reference
Description of key information
The test item showed no toxic potential at concentrations at or above the water solubility. The NOEC was determined to be > 0.05 mg/L and thus higher than the limit of water solubility.
Key value for chemical safety assessment
Additional information
The study was performed according to the OECD Guideline for Testing of Chemicals 305 (Bioconcentration: Flow-through Fish Test) adopted on June 14, 1996 using two test item concentrations for exposure to Cyprinus carpio. The purpose of this study was to determine the bioconcentration potential of the test material in fish under flow-through conditions. During the GLP compliant test the lethal and other effects in fish were determined during the exposure period of 28 days. Two environmental concentrations of the test item were used in this study - 0.05 and 0.005 mg/L. The exposure concentration was maintained using Tween 80 as solubiliser. The concentrations were verified analytically using a HPLC method with UV detection. There was no mortality and no signs of toxicity detected throughout the study in any dose group up to 28 days of exposure. The test item showed no relevant toxic potential at concentrations above the limit of the water solubility. The NOEC at 14-d and 28-d exposure was determined to be >0.05 mg/L (reference 6.1.2-1).
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