Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24-10-2003 to 14-11-2003
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected: December 2002; signature: February 2003
Type of method:
flask method
Water solubility:
556 mg/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
5.1
Remarks on result:
other: Determination of A (shaken 24 hours at 30 ºC): Equilibrated at 20°C 24 hours
Water solubility:
560 mg/L
Conc. based on:
test mat.
Incubation duration:
48 h
Temp.:
20 °C
pH:
7.2
Remarks on result:
other: Determination of B (shaken 48 hours at 30 ºC): Equilibrated at 20°C 24 hours
Water solubility:
577 mg/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
5.3
Remarks on result:
other: Determination of C (shaken 72 hours at 30 ºC): Equilibrated at 20°C 24 hours
Water solubility:
564 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
6
Remarks on result:
other: Mean concentration A/B/C: 564 mg/L at 20.0 ± 0.5°C

The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 559 mg/L.

Conclusions:
Interpretation of results: moderately soluble (100-1000 mg/L)
The substance water solubility was determined to be 564 mg/L of solution at 20.0 ± 0.5 °C.
Executive summary:

The water solubility of the test item was determined using the flask method according to EU Method A.6 and OECD Method 105 under GLP. In the definitive test, mixtures of test item and purified water were added to three separate flasks. The mass of test item was measured and the 100mL volume of water added. The flasks were shaken approximately 30°C for 24, 48 and 72 hours, respectively. Followed by static equilibration at 20°C for a period of 24 hours. The solutions were centrifuged at 13500 rpm for 10 minutes and analysed. The pH of each solution was also measured. The water solubility of the test item was determined to be 564 mg/L of solution at 20.0 ± 0.5 °C and approximately pH 7.0.

Description of key information

Water Solubility: 564 mg/L at 20 ± 0.5 °C and pH 7.0, EU Method A.6 – flask method, 2003

Key value for chemical safety assessment

Water solubility:
564 mg/L
at the temperature of:
20 °C

Additional information

Key Study : EU Method A.6, 2003 : The water solubility of the test item was determined using the flask method according to EU Method A.6 and OECD Method 105 under GLP. In the definitive test, mixtures of test item and purified water were added to three separate flasks. The mass of test item was measured and the 100mL volume of water added. The flasks were shaken approximately 30°C for 24, 48 and 72 hours, respectively. Followed by static equilibration at 20°C for a period of 24 hours. The solutions were centrifuged at 13500 rpm for 10 minutes and analysed. The pH of each solution was also measured. The water solubility of the test item was determined to be 564 mg/L of solution at 20.0 ± 0.5 °C and approximately pH 7.0.