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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 Jan 2019 - 14 Feb 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
(S)-2-(5-Oxo-3-propyl-1,2-dihydropyrrol-1-yl) butyramide
Cas Number:
357338-13-7
Molecular formula:
C11H18N2O2
IUPAC Name:
(S)-2-(5-Oxo-3-propyl-1,2-dihydropyrrol-1-yl) butyramide
Test material form:
solid: particulate/powder
Details on test material:
- Appearance: Off-white powder
- Storage condition of test material: In refrigerator protected from light
Specific details on test material used for the study:
Decomposition temp.: 250°C

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
<= 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
<= 0 Pa

Any other information on results incl. tables

Table: Results of the vapour pressure isothermal TGA analysis (substance):

Temperature
[°C]

Weight loss
[µg/min]

νT
[g/cm2/h]

logνT

logPT

PT
[Pa]

100

0.827012

9.87 x 10-5

-4.01

-0.01

0.97

 

0.751190

8.97 x 10-5

-4.05

-0.06

0.86

110

1.58243

1.89 x 10-4

-3.72

0.35

2.2

 

1.48332

1.77 x 10-4

-3.75

0.31

2.0

120

3.05497

3.65 x 10-4

-3.44

0.71

5.1

 

2.93233

3.50 x 10-4

-3.46

0.68

4.8

130

5.74671

6.86 x 10-4

-3.16

1.05

11

 

5.59520

6.68 x 10-4

-3.18

1.04

11

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance at 20°C and 25°C was determined to be ≤ 9.3E-5 Pa and ≤ 1.9E-4 Pa, resp.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study based on EC A.4, OECD 104 and OPPTS 830.7950. Validation of the method was performed using a set of five reference substances.

The vapour pressure regression curve (log PT as function of 1/T; with T in K) of the substance was constructed from weight losses measured at 100°C, 110°C, 120°C and 130°C.

The vapour pressure of the substance at 20°C and 25°C was calculated from the vapour pressure curve.

Since the weight losses of the test item were obtained with a temperature program of above the melting temperature of the test item, the vapour pressure of the test item could be slightly overestimated. The vapour pressure of the substance at 20°C and 25°C was therefore reported as ≤ 9.3E-5 Pa and ≤ 1.9E-4 Pa, resp.