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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Key result
Water solubility:
1.15 mg/L
Conc. based on:
test mat.
20 °C
>= 6 - <= 6.8
Details on results:
In a pre- test for solubility, performed during validation, the solubility of the test item in water was estimated as < 10 mg/L.
The column elution method was used for the determination of the solubility of the test item in water.
Quartz sand was mixed with test item and filled into an empty HPLC column with very fine mesh from inox on both sides.
A flow rate of 24.7 mL/h was set. After discarding the first column eluate, six consecutive fractions were collected and measured. The variation of the test item concentration in the fractions was less than 30 %, and no upward tendency was observed. Therefore, the plateau was considered as reached.
A second run with a flow rate of 12.6 mL/h was performed likewise.
Water solubility of the substance found to be 1.15 ± 0.08 mg/L at 20 ± 0.5 °C
Executive summary:

Water solubility of the substance found to be 1.15 ± 0.08 mg/L at 20 ± 0.5 °C

Description of key information

Key value for chemical safety assessment

Water solubility:
1.15 mg/L
at the temperature of:
20 °C

Additional information