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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2018 - Dec 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < -5.3
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not determined
- Details on results:
- The preliminary test at room temperature showed, that the octanol solubility of the test item seemed to be < 1.6 g/L.
With the water solubility of > 2222.8 g/L, estimated in study CSL-18-0481.04, and the estimated solubility in octanol from this preliminary test, the partition coefficient can be estimated to be below -3.
Partition coefficients (log Pow) below -2 can only be estimated from the solubilities in the pure solvents water and octanol. Thus, the estimation of the log Pow was carried out by determining the solubility in 1-octanol by means of the flask method.
For the main test three flasks were prepared with an amount of test item and 1-octanol, and one flask only with 1-octanol (blank). After stirring and centrifugation the octanol phases were measured by means of HPLC. The solution of each flask has been measured twice.
Since no signal of the test item could be observed in the measurements it can be assumed that the solubility of the test item in 1-octanol is below the LOD of 12.4 mg/L. - Conclusions:
- The partition coefficient at 20 °C of the test item was calculated from the solubilities in water and 1-octanol, according to OECD Test Guideline 105 (1995) and 107 (1995):
log POW < -5.3 - Executive summary:
The partition coefficient at 20 °C of the test item was calculated from the solubilities in water and 1-octanol, according to OECD Test Guideline 105 (1995) and 107 (1995) in GLP-compliance.
The log POW is below -5.3.
Reference
Description of key information
The partition coefficient at 20 °C of the test item was calculated from the solubilities in water and 1-octanol, according to OECD Test Guideline 105 (1995) and 107 (1995) in GLP-compliance.
The log POW is below -5.3.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -5.3
- at the temperature of:
- 20 °C
Additional information
The partition coefficient is calculated from the solubilities in ater and 1 -octanol. Therefore is the value below the stated value for the CSA.
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