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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 628 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- In this reproduction study, FeNa-EDDHMA had no effect on the survival of Daphnia magna at concentrations up to and including 1000 mg/L. A biologically relevant effect on reproductive capacity of Daphnia magna was noted at 1000 mg/L, resulting in a NOEC and EC50 for reproduction of 320 mg/L and 628 mg/L, respectively
Based on the structural similarity, the similar physico-chemical properties and the similar toxicity to aquatic invertebrates and algae between FeNa-EDDHMA and MEAHA-Fe, identical conclusions are drawn for the read-across target MEAHA-Fe. - Executive summary:
The effects of the FeNa-EDDHMA on survival and reproductive Performance in Daphnia magna during 21 days of exposure were investigated in an OECD guideline No. 211 "Daphnia magna Reproduction Test".
The nominal concentrations tested were 10, 32, 100, 320 and 1000 mg/L. Duration of the study was 21 days and the test solutions were renewed three times a week. 10 neonate daphnia for the test concentrations and 20 neonate daphnia for the control group were investigated. At the start of the test and every workday, the condition of the parental daphnia was recorded and during the reproduction phase the number of living offspring, immobile young and the presence of unhatched eggs were recorded. During the study duplicate samples of 10 ml were taken from freshly prepared solutions on days 0, 7, 14 and 19, from 72-hour old solutions on day 3 and from 48-hour old solutions on day 21. Samples were stored in a deep-freeze until possible anaiysis.
Analysis of the samples showed that the method of preparation of test media provided repeatable recoveries of test substance concentration. Measured concentrations were all in agreement with nominal, except for those measured in the samples taken at 1000 mg/L (85% - 89%) during the 2 -day period after the last renewal. Further, the measured concentrations were stable during the periods between renewals of the test solutions.
No mortality or other visible effects were recorded for the parental organisms at any of the test item concentrations tested.During the total exposure period of 21 days, no significant (greater than 10%) immobilisation (including mortality) of newborn young was observed at any of the test concentrations.
In conclusion the FeNa-EDDHMA had no effect on the survival of Daphnia magna at concentrations up to and including 1000 mg/L in this reproduction study. The test item affected the reproductive capacity of Daphnia magna at concentrations of 320 and 1000 mg/L. A biologically relevant effect on reproductive capacity of Daphnia magna was noted at 1000 mg/L.
Based on the structural similarity, the similar physico-chemical properties and the similar toxicity to aquatic invertebrates and algae between FeNa-EDDHMA and MEAHA-Fe, identical conclusions are drawn for the read-across target MEAHA-Fe.
Reference
Description of key information
Read across to structural analogue FeNa-EDDHMA.
In this long-term study FeNa-EDDHMA had no effect on the survival of Daphnia magna at concentrations up to and including 1000 mg/L. A NOEC of 320 mg/L was derived based on reproduction and greater than or equal to 1000 mg/L based on parental mortality.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 320 mg/L
Additional information
Read across to structural analogue FeEDDHMANa. For justification of read across see IUCLID section 13.
The acute toxicity to Daphnia magna was performed according to OECD guideline 211. An EC50 of 628 mg/L based on reproduction and an EC50 of greater than 1000 mg/L based on parental mortality was detected. The animals were exposed to FeNa-EDDHMA for 21 days in a static test system (Akzo Nobel Chemicals B.V., 1996). A NOEC of 320 mg/L was derived based on reproduction and greater than or equal to 1000 mg/L based on parental mortality.
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