Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 120 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 120 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- In conclusion the 96 hour LC50 value for FeNa-EDDHA with the zebrafish (Danio rerio) was > 120 mg/L based on the nominal concentration of the test substance and > 122 mg/L based on the mean of analytically determined concentrations. The 96 hour NOEC was determined to be greater than or equal to 120 mg/L.
Based on the structural similarity, the similar physico-chemical properties and the similar toxicity to aquatic invertebrates and algae between FeNa-EDDHA and MEAHA-Fe, identical conclusions are drawn for the read-across target MEAHA-Fe. - Executive summary:
The acute toxic effects (lethality) of FeNa-EDDHA to zebrafish over a 96 hour static exposure period were determined according to the principles of OECD-Guideline 203 and EU method C.1 (limit test). The test substance was tested at 120 mg/L, which was analytically confirmed.
The 96 hour LC50 value for FeNaEDDHA with the zebrafish (Danio rerio) was greater than 120 mg/L based on the nominal concentration of the test substance and greater than 122 mg/L based on the mean of analytically determined concentrations. The 96 hour NOEC was determined to be greater than or equal to 120 mg/L. Since the analytically determined concentrations of the test substance in the test solutions were within +/- 20% of the nominal concentrations, the effect concentration is expressed relative to the nominal concentration.
Based on the structural similarity, the similar physico-chemical properties and the similar toxicity to aquatic invertebrates and algae between FeNa-EDDHA and MEAHA-Fe, identical conclusions are drawn for the read-across target MEAHA-Fe.
Reference
Description of key information
The acute toxic effects (lethality) of FeNaEDDHA to zebrafish over a 96 hour static exposure period were determined according to the principles of OECD-Guideline 203 and EU method C.1 (limit test). The test substance was tested at 120 mg/L, which was analytically confirmed.
The 96 hour LC50 value for FeNaEDDHA with the zebrafish (Danio rerio) was greater than 120 mg/L based on the nominal concentration of the test substance and greater than 122 mg/L based on the mean of analytically determined concentrations. The 96 hour NOEC was determined to be greater than or equal to 120 mg/L. Since the analytically determined concentrations of the test substance in the test solutions were within +/- 20% of the nominal concentrations, the effect concentration is expressed relative to the nominal concentration.
Based on the structural similarity, the similar physico-chemical properties and the similar toxicity to aquatic invertebrates and algae between FeNa-EDDHA and MEAHA-Fe, identical conclusions are drawn for the read-across target MEAHA-Fe.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 120 mg/L
Additional information
In the key study the acute toxic effects of FeNa-EDDHA to zebrafish were determined according to the principles of OECD-Guideline 203 and EU method C.1. A limit test with a nominal concentration of 120 mg/L was carried out in a static system. The LC50 for a 96 hour exposure was greater than 120 mg/L and the NOEC was greater than or equal to 120 mg/L for zebrafish.
The supporting acute toxicity study to rainbow trout, carp, catfish and bluegill was performed according to the method reported by Bathe et al. (1974). Various concentrations of FeNa-EDDHA were prepared by adding the test material dissolved in aqua dest. (stock solution), at the appropriate amount ensuring that the total volume in each vessel remained the same. The LC50 for a 96 hour exposure was greater than 100 mg/L for Rainbow trout, Carp, Catfish and Bluegill.
Based on the structural similarity, the similar physico-chemical properties and the similar toxicity to aquatic invertebrates and algae between FeNa-EDDHA and MEAHA-Fe, identical conclusions are drawn for the read-across target MEAHA-Fe.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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