1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone

Endpoint summary

Key value for chemical safety assessment

Effects on developmental toxicity

Description of key information

The substance was predicted to be toxicant.

Link to relevant study records

Reference

Endpoint:

developmental toxicity

Type of information:

(Q)SAR

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF).

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Specific details on test material used for the study:

CC(=O)N1C2=CC=CC=C2CCC3=CC=CC=C31

Developmental effects observed:

yes

The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.

Conclusions:

The substance was predicted to be toxicant.

Effect on developmental toxicity: via oral route

Endpoint conclusion:

adverse effect observed

Justification for classification or non-classification

 Although the molecule is reliably predicted to be toxicant for development, data available are deemed to be inconclusive for the classification in accordance with CLP regulation.