Registration Dossier
Registration Dossier
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EC number: 840-270-4 | CAS number: 13080-75-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The reliability assessment of the prediction is presented in the attached document (QPRF).
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
- Specific details on test material used for the study:
- CC(=O)N1C2=CC=CC=C2CCC3=CC=CC=C31
- Test organisms (species):
- other: Fish
- Dose descriptor:
- LC50
- Effect conc.:
- 16.03 mg/L
- Sublethal observations / clinical signs:
The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The fish LC50 of the substance was predicted to be 16.03 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF).
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
- Specific details on test material used for the study:
- CC(=O)N1C2=CC=CC=C2CCC3=CC=CC=C31
- Test organisms (species):
- other: Fish
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 - <= 100 mg/L
- Sublethal observations / clinical signs:
The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The fish LC50 of the substance was predicted to be between 10 and 100 mg/L
Referenceopen allclose all
Description of key information
Based on the weight of evidence, fish LC50 is predicted to fall between 10 - 100 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 16.03 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
