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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

An assessment was conducted based on experimental data on analogous substance supported by information on toxicokinetics profile of 4,4’-isopropylidenediphenol, reaction products with 1-chloro-2,3-epoxypropane, mono, di and triesters with acrylic acid (EC 948-054-2). It was concluded it should be classified as Skin Sens. 1; H317. It is not considered necessary to carry out further testing.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vitro
Type of information:
other: expert assessment
Adequacy of study:
key study
Study period:
2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: assessment based on experimental data on analogous substance supported by information on toxicokinetics profile
Qualifier:
no guideline required
Principles of method if other than guideline:
Assessment based on experimental data on analogous substance supported by information on toxicokinetics profile
GLP compliance:
no
Type of study:
other: assessment based on experimental data on analogous substance supported by information on toxicokinetics profile
Key result
Parameter:
other: assessment based on experimental data on analogous substance supported by information on toxicokinetics profile
Vehicle controls validity:
not applicable
Negative controls validity:
not applicable
Positive controls validity:
not applicable
Remarks on result:
positive indication of skin sensitisation
Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria
Conclusions:
4,4’-isopropylidenediphenol, reaction products with 1-chloro-2,3-epoxypropane, mono, di and triesters with acrylic acid (EC 948-054-2) should be classified as Skin Sens. 1; H317.
Executive summary:

An assessment was conducted based on experimental data on analogous substance supported by information on toxicokinetics profile of 4,4’-isopropylidenediphenol, reaction products with 1-chloro-2,3-epoxypropane, mono, di and triesters with acrylic acid (EC 948-054-2). It was concluded it should be classified as Skin Sens. 1; H317. It is not considered necessary to carry out further testing.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)

Justification for classification or non-classification

4,4’-isopropylidenediphenol, reaction products with 1-chloro-2,3-epoxypropane, mono, di and triesters with acrylic acid (EC 948-054-2) should be classified as Skin Sens. 1; H317.