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EC number: 619-372-6 | CAS number: 98730-04-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 February 1986 to 6 March 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2-dichloro-1-[(3R)-3-methyl-3,4-dihydro-2H-1,4-benzoxazin-4-yl]ethan-1-one; 2,2-dichloro-1-[(3S)-3-methyl-3,4-dihydro-2H-1,4-benzoxazin-4-yl]ethan-1-one
- EC Number:
- 619-372-6
- Cas Number:
- 98730-04-2
- Molecular formula:
- C11H11Cl2NO2
- IUPAC Name:
- 2,2-dichloro-1-[(3R)-3-methyl-3,4-dihydro-2H-1,4-benzoxazin-4-yl]ethan-1-one; 2,2-dichloro-1-[(3S)-3-methyl-3,4-dihydro-2H-1,4-benzoxazin-4-yl]ethan-1-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Two groups of 8 to 10 week old Sprague Dawley rats (5 animals/sex).
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The test material was supplied as a powder and tested as received. The test atmosphere was generated using a Teost Air Mill fed via a revolving disc driven by a Sage motor. The chamber concentration was controlled by adjusting generator conditions.
The gravimetric chamber concentrationd of the test substance was determined hourly from samples collected by means of an
open-faced filter placed near the breathing zone of the animals. The nominal chamber concentratione was also calculated. Particle size analyses were conducted on hourly samples taken from the chamber using a Sierra cascade impactor. The mass median diameter and its geometric standard deviation were derived from a log-normal plot of cumulative mass of test substance deposited on each successive stage of the impactor against the stage's effective cut-off size diameter.
The hourly gravimetric chamber concentrations for Group 2 ranged from 1.9 to 2.1 mg/L with a 4-hour average value of 2.0 mg/L.
The hourly mass median diameter (MMD) and geometric standard deviation for the test atmosphere ranged from from 7.2 to 13.0 µm. (geometric SD = 2.2 to 2.6). Approximately 51% of the particles collected had an equivalent aerodynamic diameter of less than or equal to 9 µm.
Animals were exposed to control air or to 2000 mg/m3 CGA 154281 for 4 consecutive hours. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- measured every hour and ranged from 1.9 to 2.1 mg/L.
- Duration of exposure:
- 4 h
- Concentrations:
- 2000 mg/m3
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- 14 days observation period with observations of mortality, clinical signs and bodyweight. Gross pathology examination of animals at termination.
- Statistics:
- Not applicable.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 000 mg/m³ air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: based on 100% survival at the highest dose tested
- Mortality:
- No mortality was observed during the 14-day observation period.
- Clinical signs:
- other: Control animals were asymptomatic. In treated animals lacrimation, chromodacryorrhea, rhinorrhea, chromorhinorrhea, red stains around the facial area, salivation, dehydration, anorexia and few feces were observed. All rats recovered within 7 days.
- Body weight:
- Body weight gain was comparable between the groups.
- Gross pathology:
- At necropsy, no treatment-related findings were recorded. Mean lung weights of treated animals were comparable to the control values.
Any other information on results incl. tables
All rats survived treatment and only mild clinical signs were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study the inhalation LC50 for a 4 hour exposure period was determined to be greater than 2000 mg/m3.
- Executive summary:
Male and female rats were exposed, whole body, for 4 hours to an atmosphere containing benoxacor (CGA154281 Technical) at a concentration of 2.0 mg/L (MMD = 9.0 µm, GSD = 2.3). All rats survived treatment. Clinical signs were observed.
Based on the absence of signs of toxicity in the limit exposure conditions, benoxacor is considered to be of low acute inhalation toxicity and the median lethal dose was found to exceed 2 mg/L air.
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