Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline is specified in the report.
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-[(4-aminobenzoyl)amino]propanoic acid
EC Number:
616-017-7
Cas Number:
7377-08-4
Molecular formula:
C10 H12 N2 O3
IUPAC Name:
3-[(4-aminobenzoyl)amino]propanoic acid

Test animals

Species:
rat
Strain:
other: Crl:CD (SD) BR
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 1% methylcellulose
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg bw
Doses:
1000 mg/kg bw
No. of animals per sex per dose:
3 animals per sex per dose
Control animals:
not specified
Details on study design:
All animals were observed for clinical signs and mortality for 7 days. At the end of the observation period, all animals were sacrificed and subjected to complete necropsy.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No mortality was observed during the test.
Clinical signs:
other: No clinical signs were observed during the test.

Applicant's summary and conclusion

Conclusions:
The acute oral non-lethal dose in rats was greater than 1000 mg/kg.