3-[(4-aminobenzoyl)amino]propanoic acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 May - 21 May 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

- Test material: 4-Aminobenzoyl-b-alanine
- Batch number: 12/18
- Purity: NLT 96%
- Storage: Room temperature

Key result

Water solubility:

11.75 g/L

Conc. based on:

test mat.

Incubation duration:

<= 3 d

Temp.:

20 °C

pH:

3.73

Details on results:

The analytical method proved to be specific, linear, precise and accurate, as follows:
Specificity: It was demonstrated that the blank (mobile phase) did not produce any peak interfering with those of the active ingredient.
Linearity: R: 0.9999; R2: 0.9997; Slope: 45.5143; Intercept: 97.1775; Confidence interval at 95% for the intercept: [-2.5628;2.5628]
Accuracy: Average recovery: 100.69 [95% confidence limits 100.18, 101.19]; RSD: 0.7%
Precision: Assay: 1.172% w/w; RSD%: 0.24

Conclusions:

The water solubility of 4-Aminobenzoyl-b-alanine at 20°C was 11.75 g/L.

Description of key information

The water solubility of 4 -Aminobenzoyl-b-alanine at 20°C was determined according to OECD Guideline 105 and was found to be 11.75 g/L.

Key value for chemical safety assessment

Water solubility:

11.75 g/L

at the temperature of:

20 °C