Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

adsorption / desorption: screening
Type of information:
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference Type:
other: QSAR-tool
Estimation Program Interface EPI Suite (TM) v4.11: KOCWIN Program (v2.00)
United States Environmental Protection Agency, Washington, DC, USA.
Bibliographic source:

Materials and methods

Principles of method if other than guideline:
KOCWIN estimates Koc using the Molecular Connectivity Index (MCI). Fragment corrections are applied the estimation method.
GLP compliance:

Results and discussion

Adsorption coefficient
Key result
10 L/kg
Remarks on result:
other: calculated

Any other information on results incl. tables

KOCWIN Program (v2.00) Results:



CHEM  : 1-[bis(2-hydroxyethyl)amino]propan-2-ol

MOL FOR: C7 H17 N1 O3

MOL WT : 163.22

--------------------------- KOCWIN v2.00 Results ---------------------------


Koc Estimate from MCI:


First Order Molecular Connectivity Index ........... : 5.202

Non-Corrected Log Koc (0.5213 MCI + 0.60) .......... : 3.3116

Fragment Correction(s):

3  Nitrogen to Carbon (aliphatic) (-N-C).. : -0.6382

2  Aliphatic Alcohol (-C-OH) ........... : -2.6358

Corrected Log Koc .................................. : 0.0375

Over Correction Adjustment to Lower Limit Log Koc ... : 1.0000


Estimated Koc: 10 L/kg  <===========

Applicant's summary and conclusion