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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

water solubility
Type of information:
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference Type:
other: QSAR-tool
Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.11: (WSKOW v1.42)
United States Environmental Protection Agency, Washington, DC, USA.
Bibliographic source:

Materials and methods

Principles of method if other than guideline:
WSKOW accepts experimental Log Kow and MP values, and its accuracy greatly improved if an experimental MP is entered.
Type of method:
other: calculation

Results and discussion

Water solubility
Key result
Water solubility:
1 000 000 mg/L
25 °C
Remarks on result:
other: calculated

Any other information on results incl. tables

Water Sol from Kow (WSKOW v1.42) Results:



Water Sol: 1e+006 mg/L



CHEM  : 1-[bis(2-hydroxyethyl)amino]propan-2-ol

MOL FOR: C7 H17 N1 O3

MOL WT : 163.22

---------------------------------- WSKOW v1.42 Results ------------------------

Log Kow (estimated) : -2.06

Log Kow (experimental): not available from database

Log Kow used by Water solubility estimates: -2.06


Equation Used to Make Water Sol estimate:

Log S (mol/L) = 0.796 - 0.854 log Kow - 0.00728 MW + Correction

(used when Melting Point NOT available)


Correction(s):        Value

--------------------  -----

Amine, aliphatic     1.008


Log Water Solubility (in moles/L) : 2.374

Log Water Solubility (in moles/L) : 0.787 (Applied Upper Limit)

Water Solubility at 25 deg C (mg/L): 1e+006

Applicant's summary and conclusion