Registration Dossier
Registration Dossier
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EC number: 279-899-9 | CAS number: 82089-64-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2018-06-25 to 2018-07-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- Version / remarks:
- 2009
- Deviations:
- yes
- Remarks:
- It proved impossible to generate a suitable vapour atmosphere of the test item which would be in compliance with the test guideline. This was considered not to have affected the validity of the study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.52 (Acute Inhalation Toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2014
- Deviations:
- yes
- Remarks:
- It proved impossible to generate a suitable vapour atmosphere of the test item which would be in compliance with the test guideline. This was considered not to have affected the validity of the study.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- (ethyl acetoacetato-O1',O3)(pentane-2,4-dionato-O,O')[propane-1,3-diolato(2-)-O,O']titanium
- EC Number:
- 279-899-9
- EC Name:
- (ethyl acetoacetato-O1',O3)(pentane-2,4-dionato-O,O')[propane-1,3-diolato(2-)-O,O']titanium
- Cas Number:
- 82089-64-3
- Molecular formula:
- C14H22O7Ti
- IUPAC Name:
- 13-ethoxy-8,10,15-trimethyl-1λ³,5λ³-dioxa-7λ³,11λ³,12,16-tetraoxa-6-titanaspiro[5.5⁶.5⁶]hexadeca-7,10-diene-6,6,6,6-tetrakis(ylium)-1,5,9,14-tetraide
- Test material form:
- liquid: viscous
Constituent 1
Results and discussion
Any other information on results incl. tables
The mean non-volatile component of the test item was found to be 70.88% (n=10).
The test item vapor was generated and the following results were achieved in terms of atmosphere concentrations:
Duration of Exposure (minutes) |
Flow (L/min) |
Volume of Air Sampled (L) |
Atmosphere Concentration (mg/L) |
|
Air |
Exhaust |
|||
13 |
5 |
50 |
10 |
0.0059 |
30 |
10 |
50 |
2 |
0.1199 |
42 |
15 |
50 |
1 |
0.2219 |
53 |
20 |
50 |
1 |
0.2827 |
Although it was possible to generate a vapor atmosphere of the test item, the concentrations achieved were much lower than those required by the test guidelines (0.5 to 20 mg/L). It was considered, that generation of the test item as an aerosol would not be appropriate due to the nature of the test item.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In view of the physical nature of the test item it is considered unlikely to represent a significant hazard by the inhalation route.
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