Registration Dossier
Registration Dossier
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EC number: 218-657-9 | CAS number: 2212-10-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- other: Secondary source
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Guideline:
- other: not specified
- Principles of method if other than guideline:
- Not specified.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (chloromethyl)diethoxymethylsilane
- EC Number:
- 218-657-9
- EC Name:
- (chloromethyl)diethoxymethylsilane
- Cas Number:
- 2212-10-4
- Molecular formula:
- C6H15ClO2Si
- IUPAC Name:
- (2-chloro-1,1-diethoxyethyl)silane
- Test material form:
- liquid
- Details on test material:
- Unknown purity; test material used in published study; no information on grade or analytical data included.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: inhalation. no data available whether exposure was via gas, aerosol or vapor.
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 2270 ppm; no data available whether other concentrations were tested as well.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- 2 270 ppm
- Based on:
- not specified
- Remarks on result:
- other: Details of toxic effects not reported other than lethal dose value.
- Mortality:
- yes, but no details available
- Clinical signs:
- other: no data
- Body weight:
- no data
- Gross pathology:
- no data
Any other information on results incl. tables
No data available.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In a RTECS data entry (reliability score 4) for Silane, chloromethylmethyldiethoxy- a LCLo of 2270 ppm/4h was recorded. No further details are available.
- Executive summary:
In a RTECS data entry (reliability score 4) for Silane, chloromethylmethyldiethoxy- a LCLo of 2270 ppm/4h was recorded. No further details are available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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