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EC number: 262-810-2 | CAS number: 61477-95-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Read-across justification is provided in Appendix 3 of the CSR.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline followed
- Deviations:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- not specified
- Vehicle:
- no
- Details on test solutions:
- not specified
- Test organisms (species):
- Oryzias latipes
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- no data
- Post exposure observation period:
- no data
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Conductivity:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- no data
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 59.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: no data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The short-term toxicity to fish was determined in a study conducted by the Ministry of the Environment in Japan based on OECD-GLP standard and OECD guidelines. The information cited is referred to the results of existing chemicals survey conducted by the Japanese Government. The LC50 after 96 hours was determined to be 59.5 mg/L.
- Executive summary:
The short-term toxicity to fish was determined in a study conducted by the Ministry of the Environment in Japan based on OECD-GLP standard and OECD guidelines. The information cited is referred to the results of existing chemicals survey conducted by the Japanese Government. The LC50 after 96 hours was determined to be 59.5 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The calculation was using the scientific acceptable software program as recommended in REACH Guideline R.6 under REACH Regulation (EC) No 1907/2006.
SMILES (used for QSAR prediction): C(=O)(O)c1ccc(S(=O)(O)=NCl)cc1
ID of substance (used for QSAR prediction)
EC Number 262-810-2 Registry Number 61477-95-0 PubChem CID
Chemical Name monalazone disodium
Molecular Formula C7 H6 CL1 N1 O4 S1 Molecular weight (g/mole) 235.64 - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6.
- GLP compliance:
- not specified
- Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- other: Fathead minnow
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 14 318.632 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: ECOSAR Class: Amides -acid
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ECOSAR Class: Amides -acid
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 8 511.74 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: ECOSAR Class: Neutral Organic SAR(Baseline Toxicity)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR(Baseline Toxicity)
- Sublethal observations / clinical signs:
ECOSAR Version 1.11 Results Page
SMILES : c1cc(ccc1C(=O)O)S(=O)(=O)NCL
User SMILES: c1cc(ccc1C(=O)O([Na]))S(=O)(=O)N([Na])CL
CHEM : Monalazone disodium
CAS Num: 61477-95-0
ChemID1:
MOL FOR: C7 H6 CL1 N1 O4 S1
MOL WT : 235.64
Log Kow: 0.170 (EPISuite Kowwin v1.68 Estimate)
Log Kow: (User Entered)
Log Kow: (PhysProp DB exp value - for comparison only)
Melt Pt: (User Entered for Wat Sol estimate)
Melt Pt: (deg C, PhysProp DB exp value for Wat Sol estimate)
Wat Sol: 2.029E+004 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Wat Sol: (User Entered)
Wat Sol: (PhysProp DB exp value)
--------------------------------------
Values used to Generate ECOSAR Profile
--------------------------------------
Log Kow: 0.170 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 2.029E+004 (mg/L, EPISuite WSKowwin v1.43 Estimate)
--------------------------------------
ECOSAR v1.11 Class-specific Estimations
--------------------------------------
Amides -acid
***************************************************************************
* NOTE: METAL ([Na], [Li] or [K]) HAS BEEN REMOVED FOR PROPER ESTIMATION. *
* SALTS SHOULD BE ENTERED IN ECOSAR AS THE NEUTRAL NON-SALT FORM OF THE *
* MOLECULE CORRESPONDING TO EITHER THE FREE BASE OR CONJUGATE ACID. *
* SEE HELP MENU FOR MORE INFORMATION *
***************************************************************************
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
--> Acid moeity found: Predicted values multiplied by 10
Amides -acid : Fish 96-hr LC50 14318.632
Amides -acid : Daphnid 48-hr LC50 36627.262 *
Amides -acid : Green Algae 96-hr EC50 303.437
Amides -acid : Fish ChV 8.272
Amides -acid : Daphnid ChV 613.986
Amides -acid : Green Algae ChV 131.730
Amides -acid : Fish (SW) 96-hr LC50 12415.131
Amides -acid : Mysid (SW) 96-hr LC50 440.855
=========================== ================== ======== ====== ==========
Neutral Organic SAR : Fish 96-hr LC50 8511.740
(Baseline Toxicity) : Daphnid 48-hr LC50 4081.796
: Green Algae 96-hr EC50 1512.181
: Fish ChV 681.676
: Daphnid ChV 248.753
: Green Algae ChV 271.844
Note: * = asterisk designates: Chemical may not be soluble enough to
measure this predicted effect. If the effect level exceeds the
water solubility by 10X, typically no effects at saturation (NES)
are reported.
------------------------------
Class Specific LogKow Cut-Offs
------------------------------
If the log Kow of the chemical is greater than the endpoint specific cut-offs
presented below, then no effects at saturation are expected for those endpoints.
Amides :
-------
Maximum LogKow: >8.5 (LC50)
Maximum LogKow: >8.0 (EC50,ChV)
Baseline Toxicity SAR Limitations:
---------------------------------
Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50)
Maximum LogKow: 6.4 (Green Algae EC50)
Maximum LogKow: 8.0 (ChV)
- Validity criteria fulfilled:
- not applicable
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The calculation was using the scientific acceptable software program as recommended in REACH Guideline R.6 under REACH Regulation (EC) No 1907/2006.
SMILES (used for QSAR prediction): C(=O)(O)c1ccc(S(=O)(O)=NCl)cc1
ID of substance (used for QSAR prediction)
EC Number 262-810-2 Registry Number 61477-95-0 PubChem CID
Chemical Name monalazone disodium
Molecular Formula C7 H6 CL1 N1 O4 S1 Molecular weight (g/mole) 235.64 - Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance R.6
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- SMILES (used for QSAR prediction): C(=O)(O)c1ccc(S(=O)(O)=NCl)cc1
ID of substance (used for QSAR prediction)
EC Number 262-810-2 Registry Number 61477-95-0 PubChem CID
Chemical Name monalazone disodium
Molecular Formula C7 H6 CL1 N1 O4 S1 Molecular weight (g/mole) 235.64 - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 263.436 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: Battery
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Domain: IN
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 512.353 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: Leadscope
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Domain: IN
- Validity criteria fulfilled:
- not specified
Referenceopen allclose all
Description of key information
Testing on aquatic vertebrates was considered not necessary as alternatives to animal testing were available and they demonstrated to be sufficient to fulfil the requirement of Annex VIII 9.1.3 on Short-term toxicity testing on fish. Therefore, the general rules for adaption 1.2, 1,3 and 1.5 of Annex XI of REACH regulation were applied. The results obtained from QSARs models indicated the absence of hazardous to the aquatic environment and the testing with the registered substance was considered not reasonable. Furthermore, read across data from a similar substance was used as supporting information.
The following data has been taken into account for the hazard assessment:
-96h LC50: 8511.74 mg/L (ECOSAR v1.11)
-96h LC50: 262.4361 mg/L (Danish QSAR Database)
-48h EC50: 59.5 mg/l (read across)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 262 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 262 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
