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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 August 2018 to 07 September 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
41.1 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
100 g/L
Incubation duration:
24 - 72 h
Temp.:
20 °C
pH:
5.8

- Preliminary Test

The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 37.6 g/L. The solution had a pH of 5.8.

- Definitive Test

The mean peak areas relating to the standard and sample solutions are shown in the following table:

Solution

Mean Peak Area

Standard 40.3 mg/L

2.1098 x 106

Standard 40.6 mg/L

2.1323 x 106

Matrix blank

2.7085 x 10³

Sample 1A

2.1437 x 106

Sample 1B

2.1299 x 106

Sample 2A

2.1433 x 106

Sample 2B

2.2064 x 106

Sample 3A

2.1589 x 106

Sample 3B

2.1467 x 106

 

The concentration (g/L) of test material in the sample solutions is shown in the following table:

Sample number

Time shaken at ca 31 °C (hours)

Concentration (g/L)

Solution pH

1

24

40.8

5.8

2

48

41.5

5.7

3

72

41.1

5.7

Overall concentration : 41.1 g/L at 20.0 ± 0.5 ºC

On completion of the equilibration period, the samples were clear and colourless with excess test material present. After centrifugation, the aliquots were visually observed to be clear, colourless and free from un-dissolved test material.

- Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 10 to 50 mg/L. The results were satisfactory with a correlation coefficient (r) of 0.999 being obtained.

Conclusions:
The water solubility of the test material was determined to be 41.1 g/L of solution at 20.0 ± 0.5 °C.
Executive summary:

The water solubility of the test material was investigated in a study which was conducted in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions, following the Flask Method.

Under the conditions of the study the water solubility of the test material was determined to be 41.1 g/L of solution at 20.0 ± 0.5 °C.

Description of key information

The water solubility of the test material was determined to be 41.1 g/L of solution at 20.0 ± 0.5 °C.

Key value for chemical safety assessment

Water solubility:
41.1 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was investigated in a study which was conducted in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions, following the Flask Method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study the water solubility of the test material was determined to be 41.1 g/L of solution at 20.0 ± 0.5 °C.